Molecular control of lymphangiogenesis
Identifieur interne : 009657 ( Main/Exploration ); précédent : 009656; suivant : 009658Molecular control of lymphangiogenesis
Auteurs : Megan E. Baldwin [Australie] ; Steven A. Stacker [Australie] ; Marc G. Achen [Australie]Source :
- BioEssays [ 0265-9247 ] ; 2002-11.
Descripteurs français
- KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type A, Facteurs de croissance endothéliale (métabolisme), Facteurs de croissance endothéliale vasculaire, Homéostasie, Humains, Liquides biologiques (métabolisme), Lymphokines (métabolisme), Modèles biologiques, Protéines et peptides de signalisation intercellulaire (métabolisme), Récepteurs aux facteurs de croissance endothéliale vasculaire (métabolisme), Système lymphatique (croissance et développement), Système lymphatique (physiologie), Système lymphatique (physiopathologie).
- MESH :
- croissance et développement : Système lymphatique.
- métabolisme : Facteurs de croissance endothéliale, Liquides biologiques, Lymphokines, Protéines et peptides de signalisation intercellulaire, Récepteurs aux facteurs de croissance endothéliale vasculaire.
- physiologie : Système lymphatique.
- physiopathologie : Système lymphatique.
- Animaux, Facteur de croissance endothéliale vasculaire de type A, Facteurs de croissance endothéliale vasculaire, Homéostasie, Humains, Modèles biologiques.
English descriptors
- KwdEn :
- Animals, Body Fluids (metabolism), Endothelial Growth Factors (metabolism), Homeostasis, Humans, Intercellular Signaling Peptides and Proteins (metabolism), Lymphatic System (growth & development), Lymphatic System (physiology), Lymphatic System (physiopathology), Lymphokines (metabolism), Models, Biological, Receptors, Vascular Endothelial Growth Factor (metabolism), Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors.
- MESH :
- chemical , metabolism : Endothelial Growth Factors, Intercellular Signaling Peptides and Proteins, Lymphokines, Receptors, Vascular Endothelial Growth Factor.
- growth & development : Lymphatic System.
- metabolism : Body Fluids.
- physiology : Lymphatic System.
- physiopathology : Lymphatic System.
- Animals, Homeostasis, Humans, Models, Biological, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors.
Abstract
The lymphatic vasculature plays a critical role in the regulation of body fluid volume and immune function. Extensive research into the molecular mechanisms that control blood vessel growth has led to identification of molecules that also regulate development and growth of the lymphatic vessels. This is generating a great deal of interest in the molecular control of the lymphatics in the context of embryogenesis, lymphatic disorders and tumor metastasis. Studies in animal models carried out over the past three years have shown that the soluble protein growth factors, vascular endothelial growth factor (VEGF)‐C and VEGF‐D, and their cognate receptor tyrosine kinase, VEGF receptor‐3 (VEGFR‐3), are critical regulators of lymphangiogenesis. Furthermore, disfunction of VEGFR‐3 has recently been shown to cause lymphedema. The capacity to induce lymphangiogenesis by manipulation of the VEGF‐C/VEGF‐D/VEGFR‐3 signaling pathway offers new opportunities to understand the function of the lymphatic system and to develop novel treatments for lymphatic disorders. BioEssays 24:1030–1040, 2002. © 2002 Wiley‐Periodicals, Inc.
Url:
DOI: 10.1002/bies.10173
Affiliations:
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Le document en format XML
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Extensive research into the molecular mechanisms that control blood vessel growth has led to identification of molecules that also regulate development and growth of the lymphatic vessels. This is generating a great deal of interest in the molecular control of the lymphatics in the context of embryogenesis, lymphatic disorders and tumor metastasis. Studies in animal models carried out over the past three years have shown that the soluble protein growth factors, vascular endothelial growth factor (VEGF)‐C and VEGF‐D, and their cognate receptor tyrosine kinase, VEGF receptor‐3 (VEGFR‐3), are critical regulators of lymphangiogenesis. Furthermore, disfunction of VEGFR‐3 has recently been shown to cause lymphedema. The capacity to induce lymphangiogenesis by manipulation of the VEGF‐C/VEGF‐D/VEGFR‐3 signaling pathway offers new opportunities to understand the function of the lymphatic system and to develop novel treatments for lymphatic disorders. BioEssays 24:1030–1040, 2002. © 2002 Wiley‐Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Baldwin, Megan E" sort="Baldwin, Megan E" uniqKey="Baldwin M" first="Megan E." last="Baldwin">Megan E. Baldwin</name></noRegion><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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